反应详情

500 mg of 4-(2-phenyl-chroman-6-yloxy)-cyclohexanone (1.6 mmol) were dissolved at 0° C. in 2.5 ml of ethanol. 30 mg of sodium borohydride (0.78 mmol) were added in portions, and stirring at room temperature was continued for 2 h. The solvent was removed under reduced pressure and the residue separated between saturated aqueous sodium hydrogencarbonate solution and dichloromethane. The aqueous layer was extracted with dichloromethane. The combined organic layers were dried with sodium sulfate and filtered, and volatile components removed under reduced pressure. 500 mg of the title compound were obtained as a pale yellow solid.

1. customThe solvent was removed under reduced pressure
2. customthe residue separated between saturated aqueous sodium hydrogencarbonate solution and dichloromethane
3. extractionThe aqueous layer was extracted with dichloromethane
4. dry with materialThe combined organic layers were dried with sodium sulfate
5. filtrationfiltered
6. customvolatile components removed under reduced pressure