反应详情

温度

90 °C

0.80 g of 5-(2-(3-chloropropoxy)ethyl)-1-benzothiophene was dissolved in 8 ml of N,N-dimethylformamide. Thereafter, 1.20 g of N-(3-azetidinyl)acetamide was added to the obtained solution, and the obtained mixture was stirred at 90° C. for 12 hours. After cooling, water and ethyl acetate were added to the reaction mixture, and an organic layer was separated. The organic layer was successively washed with water and a saturated saline solution, and then dried over anhydrous magnesium sulfate. Thereafter, the solvent was distilled away under a reduced pressure. The residue was purified by column chromatography (eluent; chloroform:methanol=7:1), so as to obtain 0.39 g of a light yellow oil product, N-(1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-3-azetidinyl)acetamide.

1. temperatureAfter cooling
2. customan organic layer was separated
3. washThe organic layer was successively washed with water
4. dry with materiala saturated saline solution, and then dried over anhydrous magnesium sulfate
5. distillationThereafter, the solvent was distilled away under a reduced pressure
6. customThe residue was purified by column chromatography (eluent; chloroform:methanol=7:1)