2-Methyl-propane-2-sulfinic acid [1-benzyl-4-(2-phenyl-chroman-6-yloxy)-cyclohexyl]-amide → 1-Benzyl-4-(2-phenyl-chroman-6-yloxy)-cyclohexylamine

Participants

Reaction Conditions

Reaction Steps

120 mg of 2-methyl-propane-2-sulfinic acid [1-benzyl-4-(2-phenyl-chroman-6-yloxy)-cyclohexyl]-amide (0.23 mmol) were dissolved in 2 ml of trifluoroacetic acid in a sealed microwave tube and heated in a microwave reactor for 1 h at 130° C. The solvent was removed under reduced pressure and the resulting residue purified by reversed phase HPLC chromatography. 21 mg of 1-benzyl-4-(2-phenyl-chroman-6-yloxy)-cyclohexylamine were obtained as a solid (17%).

Provenance & Evidence