反应详情

温度

85 °C

1.20 g of 5-(2-(3-chloropropoxy)ethyl)-1-benzothiophene was dissolved in 12 ml of N,N-dimethylformamide. Thereafter, 0.82 g of 3-pyrrolidinol and 1.30 g of potassium carbonate were added to the obtained solution, and the mixture was then stirred at 85° C. for 2.5 hours. After the reaction mixture was cooled, water and ethyl acetate were added thereto, and an organic layer was separated. The organic layer was successively washed with water and a saturated saline solution, and then dried over anhydrous magnesium sulfate. Thereafter, the solvent was distilled away under a reduced pressure. The residue was purified by column chromatography (eluent; chloroform:methanol=20:1 to 10:1), so as to obtain 0.78 g of an achromatic oil product, 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-3-pyrrolidinol.

1. temperatureAfter the reaction mixture was cooled
2. customan organic layer was separated
3. washThe organic layer was successively washed with water
4. dry with materiala saturated saline solution, and then dried over anhydrous magnesium sulfate
5. distillationThereafter, the solvent was distilled away under a reduced pressure
6. customThe residue was purified by column chromatography (eluent; chloroform:methanol=20:1 to 10:1)