反应详情

温度

0 °C

Combine (4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanone (0.43 g, 1.0 mmol) and methanol (15 mL) in a round bottom flask. Place under nitrogen and cool to 0° C. Add sodium borohydride (58 mg, 1.5 equiv.) in one portion. Stir for 5 min at this temperature then remove cooling bath and let warm to RT. After 15 min, quench the reaction with water then extract with EA. Wash the organics with water followed by aqueous saturated sodium chloride. Dry the organics over anhydrous magnesium sulfate. Filter and concentrate in vacuo to give the title compound (0.4 g, 93%). LCMS (4 min)=425.0, 427.0, M+1.

1. customthen remove
2. temperaturecooling bath
3. temperaturelet warm to RT
4. waitAfter 15 min
5. customquench
6. customthe reaction with water
7. extractionthen extract with EA
8. washWash the organics with water
9. dry with materialDry the organics over anhydrous magnesium sulfate
10. filtrationFilter
11. concentrationconcentrate in vacuo