反应详情

Combine 3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine (0.1 g, 0.21 mmol) and 1,4-dioxane (10 mL) in a pear flask and place under nitrogen. Add hydrogen chloride (4 M in 1,4-dioxane, 0.053 mL, 1.0 equiv.) and let stir at RT under nitrogen for 1.5 h. Concentrate in vacuo then evaporate under vacuum from absolute ethanol two times. Dry overnight in a vacuum oven (60° C.) to give the title compound (0.11 g, 102%). LCMS (8 min)=470.0, M+1.

1. concentrationConcentrate in vacuo
2. customthen evaporate under vacuum from absolute ethanol two times
3. customDry overnight in a vacuum oven (60° C.)