反应详情

The solution of allyl 4-((2-benzamidoethyl)(4-chlorophenethyl)amino)piperidine-1-carboxylate, PhSiH3 (5 equiv) in DCM (8 mL/mmol) was degassed for 10 min by bubbling argon through the inserted needle, prior to the addition of Pd(Ph3P)4 (5 mol %). After 20 min TLC indicated completion of reaction. The reaction was concentrated and was purified by column chromatography in DCM/MeOH solvent system (gradient 100:1 to 10:1) to give pure product in a form of an off-white solid.

1. customby bubbling argon through the inserted needle
2. additionto the addition of Pd(Ph3P)4 (5 mol %)
3. customAfter 20 min TLC indicated completion of reaction
4. concentrationThe reaction was concentrated
5. customwas purified by column chromatography in DCM/MeOH solvent system (gradient 100:1 to 10:1)
6. customto give pure product in a form of an off-white solid