反应详情

A 2% solution of aqueous sulfuric acid (100 ml) was added to ethyl 6-oxo-3-azabicyclo[3.2.1]octane-3-carboxylate ethylene ketal (6.72 g, 27.9 mmol) and the mixture was allowed to stir for 1 h. The mixture was then extracted with ethyl acetate (2×100 ml). The combined organic layers were dried over potassium carbonate, filtered, concentrated by rotary evaporation, and then distilled on a Kugelrohr apparatus (0.2 mm Hg, 132-162° C.) to yield a clear colorless oil (3.49 g, 64%).

1. extractionThe mixture was then extracted with ethyl acetate (2×100 ml)
2. dry with materialThe combined organic layers were dried over potassium carbonate
3. filtrationfiltered
4. concentrationconcentrated by rotary evaporation
5. distillationdistilled on a Kugelrohr apparatus (0.2 mm Hg, 132-162° C.)