Formaldehyde → HCID 57485792, compound

Participants

Reaction Steps

A sample of ethyl cyclohex-3-en-1-ylmethylcarbamate (5.1 g, 28 mmol) in 500 mL of THF was treated with paraformaldehyde (16.7 g, 560 mmol), potassium carbonate (7.8 g, 56 mmol) and cesium carbonate (1.8 g, 5.6 mmol). The mixture was stirred vigorously and heated under reflux for 4 h. The mixture was cooled, filtered and concentrated under reduced pressure. The residue was column chromatographed on silica gel, using 3:1 hexane/ethyl acetate as eluent, to give a colorless oil (3.6 g, 61%).

Provenance & Evidence