Hydrochloric Acid → HCID 67052467, compound

Participants

Reaction Steps

Hydrogen chloride (56.74 g of a 2.2 M solution in ethanol, 124.8 mmol) was added to a suspension of tert-butyl {2-[4-amino-7-bromo-2-(ethoxymethyl)-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]-1,1-dimethylethyl}carbamate (15.40 g, 31.21 mmol) in anhydrous ethanol (120 mL), and the reaction mixture was heated at reflux for four hours and allowed to cool to room temperature. A precipitate had formed and was isolated by filtration, washed with a small volume of cold ethanol, and dried in a vacuum oven at 60° C. to provide 12.26 g of 1-(2-amino-2-methylpropyl)-7-bromo-2-(ethoxymethyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine dihydrochloride.

Provenance & Evidence