2-Bromomesitylene → HCID 69433788, compound

Participants

Reaction Conditions

Reaction Steps

4-Methoxy-6-methyl-N2,N2-dipropylpyrimidin-2,5-diamine (0.022 g, 0.092 mmol) was charged with 2,4,-6-trimethylbromobenzene (16.7 μL, 0.11 mmol), rac-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) (0.012 g, 0.018 mmol), sodium t-butoxide (0.012 g, 0.13 mmol) and tris(dibenzylideneacetone) dipalladium (0) (Pd2(dba)3) (0.017 g, 0.018 mmol). The reagents were diluted in 1 mL of toluene and heated at 115° C. for 1.5 h. The solution was cooled and flash chromatographed (5% ethyl acetate/hexanes) to give 0.019 g (58%) of the title compound as an oil.

Provenance & Evidence