反应详情

To a solution containing 2.0 g (14 mmol) of 2-(methylthio)pyrimidin-4(3H)-one in 10 ml of acetic acid under a nitrogen atmosphere was added 1.04 ml (14 mmol) of bromine in 2 ml acetic acid. The reaction was allowed to stir at room temperature for 30 min. The precipitated product was filtered, washed with acetic acid and suspended in hot acetic acid. To this suspension was added 0.2 ml bromine in 1 ml acetic acid. The product was collected, washed with acetic acid and recrystallized from ethanol to yield 1.4 g (45%) of product.

1. filtrationThe precipitated product was filtered
2. washwashed with acetic acid
3. additionTo this suspension was added 0.2 ml bromine in 1 ml acetic acid
4. customThe product was collected
5. washwashed with acetic acid
6. customrecrystallized from ethanol