HCID 67267578, compound → HCID 58938583, compound

Participants

Reaction Steps

Diethyl [2-(dipropylamino)-1-ethoxy-2-(6-mesitylpyridin-2-yl)ethyl]malonate (0.65 g, 1.35 mmol), was dissolved in 5 mL of Dowtherm A (1:2 biphenyl:phenyl ether). The solution was placed in a pre-heated oil bath at 220° C. The reaction stirred at this temperature for 20 minutes. The solution was cooled and flash chromatographed (15%-35% ethyl acetate/hexanes) to give 0.28 g (48% yield) of an orange solid.

Provenance & Evidence