Methyl morpholine oxide → HCID 58938628, compound

Participants

Reaction Steps

1-(Dipropylamino)-3-(hydroxymethyl)-6-mesityl-4H-quinolizin-4-one (0.60 g, 1.53 mmol) was dissolved in dichloromethane (20 mL) and acetonitrile (4 mL). 0.5 g of crushed sieves (4 angstroms) was added followed by N-methylmorpholine N-oxide (NMO) (0.27 g, 2.3 mmol). Tetrapropylammonium perruthenate (TPAP) (0.081 g, 0.23 mmol) was added last. The reaction stirred for 0.5 h. The solution was filtered and concentrated. Flash chromatography (20% ethyl acetate/hexanes) gave 0.436 g (73% yield) of the title compound as a red solid.

Provenance & Evidence