Sodium Hydroxide → 4-(5-Methyl-pyridin-2-yl)-1-phenyl-1H-indazole-6-carboxylic acid

HRID 59812Notes

Reaction equation

C[O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([CH:9]=[N:10][N:11]2[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:7]([C:20]2[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][N:21]=2)[CH:6]=1)=[O:4].[OH-].[Na+]>>[CH3:26][C:23]1[CH:24]=[CH:25][C:20]([C:7]2[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:13]=[C:12]3[C:8]=2[CH:9]=[N:10][N:11]3[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:21][CH:22]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 596277764-(5-Methyl-pyridin-2-yl)-1-phenyl-1H-indazole-6-carboxylic acid methyl ester

Product 1

HCID 596277694-(5-Methyl-pyridin-2-yl)-1-phenyl-1H-indazole-6-carboxylic acid

Procedure

4-(5-Methyl-pyridin-2-yl)-1-phenyl-1H-indazole-6-carboxylic acid methyl ester was treated with NaOH using the procedure of step 3 of Example 1 to afford 4-(5-methyl-pyridin-2-yl)-1-phenyl-1H-indazole-6-carboxylic acid.

Sources & evidence

ORD record: ord-eaaa298eb3b84b419e609e678ac03052
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09440956B2

Reaction notes

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