Ethanol → HCID 67266806, compound

Participants

Reaction Steps

A mixture of ethyl 3-cyano-1-mesityl-1H-pyrrole-2-carboxylate (0.5 g, 1.77 mmol), hydrazine monohydrate (0.86 ml, 17.7 mmol) and ethanol (20 ml) was heated under reflux for 2 days. During the reaction, additional hydrazine monohydrate (0.86 ml×2) was added. The mixture was diluted with water (50 ml) and extracted with ethyl acetate (50 ml×2). The extracts were combined, washed with water, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by silica gel chromatography eluting with dichloromethane/ethyl acetate (3:1-1:1) to give 297 mg (63%) of the title compound as crystals.

Provenance & Evidence