Triacetoxyperiodinane → HCID 86613893, compound

Participants

Reaction Steps

To 0.20 g (0.54 mmol) of 1-benzyl-5-(2,4-dimethylphenyl)-3-(hydroxymethyl)cinnolin-4(1H)-one in 10 mL of dichloromethane was added 0.28 g (0.65 mmol) of Dess-Martin periodinane. The reaction was stirred at room temperature for 90 min before being diluted with sodium bicarbonate solution and extracted with dichloromethane. The combined organic layers were washed with brine, dried over sodium sulfate, filtered, concentrated in vacuo and purified by flash chromatography eluting with a 33% ethyl acetate/hexanes mixture to give 0.17 g (85%) of the title compound as a yellow powder.

Provenance & Evidence