Potassium Hydroxide → HCID 67266689, compound

HRID 598167Notes

Reaction equation

HRID 598167 reaction equation
[Br:1][C:2]1[N:3]=[CH:4][N:5]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][C:13]=2[CH3:19])[C:6]=1[C:7]([O:9]CC)=[O:8].[OH-].[K+]>C(O)C>[Br:1][C:2]1[N:3]=[CH:4][N:5]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][C:13]=2[CH3:19])[C:6]=1[C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 67267353HCID 67267353, compound

Product 1

HCID 67266689HCID 67266689, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 1.88 g (5.8 mmol) of ethyl 4-bromo-1-(2,4-dimethylphenyl)-1H-imidazole-5-carboxylate in 30 mL of ethanol was added 3.0 mL (18 mmol) of 6N KOH and the resulting mixture was stirred for 3 h at room temperature. Volatiles were removed in vacuo, the residue was diluted with water, washed with ether and acidified with 1N HCl. The resulting precipitate was collected by filtration and dried to give 1.54 g (90%) of the title compound as a white powder.

Workup

  1. customVolatiles were removed in vacuo
  2. additionthe residue was diluted with water
  3. washwashed with ether
  4. filtrationThe resulting precipitate was collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-c0006dd2ba1b44deaa602471830a6a7f
Source dataset
uspto-grants-2011_03
Patent number
US07897607B2

Reaction notes

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