HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 598177Generated: October 25, 2026
Sodium hydride → 5-Choro-4-oxo-1-(1-propylbutyl)-1,4-dihydroquinoline-3-carbonitrile
https://huagongshe.com/reaction/598177
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (E)-2-(2,6-dichlorobenzoyl)-3-(1-propylbutylamino)acrylonitrile | HCID 67267339 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Choro-4-oxo-1-(1-propylbutyl)-1,4-dihydroquinoline-3-carbonitrile | HCID 67267585 | 40% |
Reaction Steps
(E)-2-(2,6-dichlorobenzoyl)-3-(1-propylbutylamino)acrylonitrile (0.020 g, 0.059 mmol) was dissolved in dioxane (2 mL). Sodium hydride (0.007 g, 0.18 mmol, 60% wt. dispersion in mineral oil) was added in one portion. Reaction was heated overnight at 100° C. Solution was cooled and quenched with MeOH and concentrated. Flash chromatography gave the desired product (0.007 g, 40%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07897607B2 |
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| Source dataset | uspto-grants-2011_03 |
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| ORD ID | ord-a30f4e99ae47443fb4fb4f827b962785 |
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| Source note | uspto-grants-2011_03 |
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