Chloroacetaldehyde → 2-Amino-7-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

Participants

Reaction Steps

To a suspension of 2-amino-6-(methylamino)pyrimidin-4-ol (40.5 g, 289 mmol) in methanol (300 ml) was added 40% aqueous chloroacetoaldehyde (51.6 ml, 318 mmol) and potassium carbonate (44.0 g, 318 mmol), and the mixture was refluxed for 1 hour. After cooling, the resulting crystals were collected by filtration and washed with water to give 19.4 g (41%) of the title compound.

Provenance & Evidence