Sodium Bicarbonate → HCID 58938618, compound

Participants

Reaction Steps

A Solution of 2-(dipropylamino)-5-mesityl-7-(4-methoxybenzyl)-3-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (100 mg, 0.21 mmol) in trifluoroacetic acid (3 ml) and anisole (0.1 ml) was refluxed for 3 days. The mixture was diluted with water (20 ml), neutralized with sodium hydrogen carbonate and extracted with ethyl acetate (20 ml×2). The extracts were combined, washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by silica gel chromatography eluting with hexane/ethyl acetate (5:1) to give 12 mg (15%) of the title compound.

Provenance & Evidence