Acetyl chloride → HCID 58938663, compound

Participants

Reaction Steps

A solution of 2-(dipropylamino)-5-mesityl-3-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (20 mg, 0.054 mmol) in acetonitrile (1.5 ml) was added sodium hydride (60% in oil, 5 mg, 0.125 mmol) at 0° C. and stirred for 0.5 hour. After stirring at room temperature for 0.5 hour, to the mixture was added a solution of acetylchloride (20 mg, 0.25 mmol) and acetonitrile (0.5 ml) at 0° C. and stirred for 0.5 hour. After stirring at 80° C. for 1 hour, the mixture was diluted with water (20 ml) and extracted with ethyl acetate (20 ml×3). The extracts were combined, washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by silica gel chromatography eluting with hexane/ethyl acetate (10:1) to give 17 mg (77%) of the title compound.

Provenance & Evidence