1-Methyl-1h-imidazo[4,5-b]pyridin-2(3h)-one → N-(2-Methylbenzyl)-1-methyl-2-oxo-1,2-dihydroimidazo[4,5-b]pyridine-3-carboxamide

HRID 598199Notes

Reaction equation

HRID 598199 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]1=[O:11].[N:12]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH3:22])=[C:13]=[O:14]>O1CCOCC1>[CH3:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[CH2:15][NH:12][C:13]([N:4]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:10]2[N:2]([CH3:1])[C:3]1=[O:11])=[O:14]

Participants

4

Reactant 2

HCID 8542361-Methyl-1h-imidazo[4,5-b]pyridin-2(3h)-oneHCID 27333861-(Isocyanatomethyl)-2-methylbenzene

Product 1

HCID 67267754N-(2-Methylbenzyl)-1-methyl-2-oxo-1,2-dihydroimidazo[4,5-b]pyridine-3-carboxamide

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Analogously to Example 1, 75 mg (0.5 mmol) of 1-methyl-1,3-dihydroimidazo[4,5-b]pyridin-2-one were reacted with 74 mg (0.5 mmol) of 1-isocyanatomethyl-2-methylbenzene in dioxane at 80° C. Yield: 11 mg (7%), M+H+: 297.05.

Sources & evidence

ORD record
ord-b317482dd7e9427da15ed54b33f684a0
Source dataset
uspto-grants-2011_03
Patent number
US07897616B2

Reaction notes

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