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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 598230Generated: October 30, 2026

3,4-Dichlorobenzeneboronic acid → N-(2-cyclopropyl-2-hydroxy-propyl)-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide

https://huagongshe.com/reaction/598230

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-Dichlorobenzeneboronic acidHCID 2734330—
Reactant5-Bromo-N-(2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamideHCID 86634798—
ProductN-(2-cyclopropyl-2-hydroxy-propyl)-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamideHCID 44240720—

Reaction Steps

The title compound was synthesized in analogy to Example 1d, using 5-bromo-N-(2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide and 3,4-dichlorophenylboronic acid as starting materials, MS (ISP) 531.0, 533.0 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07897621B2
Source datasetuspto-grants-2011_03
ORD IDord-2f42b1f542304c2e98105572a8f1d20c
Source noteuspto-grants-2011_03