HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-1-amino-2-cyclopropyl-propan-2-ol → 5-Bromo-N-((R)-2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-1-amino-2-cyclopropyl-propan-2-ol | HCID 51684102 | — |
| Reactant | 5-Bromo-6-(2,2,2-trifluoroethoxy)-2-(trifluoromethyl)nicotinic acid | HCID 86346320 | — |
| Product | 5-Bromo-N-((R)-2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide | HCID 86634799 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1c, using 5-bromo-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinic acid and (R)-α-(aminomethyl)-α-methyl-cyclopropanemethanol as starting materials, MS (ISP) 462.9, 464.9 (M−H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897621B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-8783d70067be4e03a55b34d7af698eed |
| Source note | uspto-grants-2011_03 |