HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-1-Amino-2-cyclopropylpropan-2-ol → 5-Bromo-N-((S)-2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-1-Amino-2-cyclopropylpropan-2-ol | HCID 51684100 | — |
| Reactant | 5-Bromo-6-(2,2,2-trifluoroethoxy)-2-(trifluoromethyl)nicotinic acid | HCID 86346320 | — |
| Product | 5-Bromo-N-((S)-2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide | HCID 86634800 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1c, using 5-bromo-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinic acid and (S)-α-(aminomethyl)-α-methyl-cyclopropanemethanol as starting materials, MS (ISP) 465.0, 467.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897621B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-ce5f3553cd094d8485398a1dcc17acd2 |
| Source note | uspto-grants-2011_03 |