HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Chlorophenyl)boronic acid → 5-(3-chloro-phenyl)-N-(2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Chlorophenyl)boronic acid | HCID 2734323 | — |
| Reactant | 5-Bromo-N-(2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide | HCID 86634798 | — |
| Product | 5-(3-chloro-phenyl)-N-(2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide | HCID 44240723 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1d, using 5-bromo-N-(2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide and 3-chlorophenylboronic acid as starting materials, MS (ISP) 531.0, 497.1 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897621B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-a85d4ebdf587456a96bafe2a8ef7b0f7 |
| Source note | uspto-grants-2011_03 |