HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzeneacetonitrile, 4-fluoro- → 3-(4-Fluoro-phenyl)-5-[2-(4-fluoro-phenyl)-2H-pyrazol-3-yl]-benzo[c]isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzeneacetonitrile, 4-fluoro- | HCID 68016 | — |
| Reactant | 1-(4-fluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole | HCID 90033399 | — |
| Product | 3-(4-Fluoro-phenyl)-5-[2-(4-fluoro-phenyl)-2H-pyrazol-3-yl]-benzo[c]isoxazole | HCID 73052849 | — |
Reaction Steps
The title compound, light yellow solid (41 mg, 31%), MS (ISP) m/z=374.1 [(M+H)+], mp 159° C., was prepared in accordance with the general method of example 1 from 1-(4-fluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate C) (100 mg, 353 μmol) and commercially available 2-(4-fluoro-phenyl)-acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440962B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-fae072bb986f4a439b018eafb7105ddd |
| Source note | uspto-grants-2016_09 |