反应详情

5-Bromo-N-((1RS,2SR)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide (103 g) was subjected to chiral chromatography on ChiralPak AD with 5% isopropanol/n-heptane as eluent. The product eluted as second peak to give after evaporation of the solvent the title compound (43.3 g) as a white solid, MS (ISP) 465.0, 467.0 (M+H)+; [α]D20+19.1°.

1. washThe product eluted as second peak
2. customto give
3. customafter evaporation of the solvent the title compound (43.3 g) as a white solid, MS (ISP) 465.0, 467.0 (M+H)+