HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-N-((1RS,2SR)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide → 5-bromo-N-((1S,2R)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-N-((1RS,2SR)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide | HCID 86634803 | — |
| Solvent | Isopropanol heptane | HCID 21225753 | — |
| Product | 5-bromo-N-((1S,2R)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide | HCID 86634806 | — |
Reaction Steps
5-Bromo-N-((1RS,2SR)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide (103 g) was subjected to chiral chromatography on ChiralPak AD with 5% isopropanol/n-heptane as eluent. The product eluted as first peak to give after evaporation of the solvent the title compound (42.4 g) as a white solid, MS (ISP) 465.0, 467.0 (M+H)+; [α]D20=−19.8°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897621B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-d309d5f9f1a8433eb79c9aca722435f6 |
| Source note | uspto-grants-2011_03 |