HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenylboronic acid → 5-(4-Chloro-phenyl)-N-((1S,2R)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Reactant | 5-bromo-N-((1S,2R)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide | HCID 86634806 | — |
| Product | 5-(4-Chloro-phenyl)-N-((1S,2R)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide | HCID 44240771 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1d, using 5-bromo-N-((1S,2R)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide and 4-chlorophenylboronic acid as starting materials, MS (ISP) 497.1 (M+H)+; [α]D20=−20.0°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897621B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-4bdbf3cc63b54ed0aaec05ec16ff3faf |
| Source note | uspto-grants-2011_03 |