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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 598255Generated: October 29, 2026

(1R,2R)-2-Aminocyclohexanol → 5-Bromo-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamide

https://huagongshe.com/reaction/598255

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1R,2R)-2-AminocyclohexanolHCID 735777—
Reactant5-Bromo-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinic acidHCID 57446301—
Product5-Bromo-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamideHCID 68970962—

Reaction Steps

The title compound was synthesized in analogy to Example 1c, using 5-bromo-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinic acid and (1R,2R)-2-amino-cyclohexanol as starting materials, MS (ISP) 476.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07897621B2
Source datasetuspto-grants-2011_03
ORD IDord-d909b0e102044f0e89f167fc707ae819
Source noteuspto-grants-2011_03