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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 598256Generated: October 30, 2026

3,4-Dichlorobenzeneboronic acid → 5-(3,4-Dichloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamide

https://huagongshe.com/reaction/598256

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-Dichlorobenzeneboronic acidHCID 2734330—
Reactant5-Bromo-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamideHCID 68970962—
Product5-(3,4-Dichloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamideHCID 44240775—

Reaction Steps

The title compound was synthesized in analogy to Example 1d, using 5-bromo-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamide and 3,4-dichlorophenylboronic acid as starting materials, MS (ISP) 540.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07897621B2
Source datasetuspto-grants-2011_03
ORD IDord-0b51d383803f4af69c4429ab4ce6b5d6
Source noteuspto-grants-2011_03