HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzeneacetonitrile, 4-fluoro- → 3-(4-Fluoro-phenyl)-5-(2-p-tolyl-2H-pyrazol-3-yl)-benzo[c]isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzeneacetonitrile, 4-fluoro- | HCID 68016 | — |
| Reactant | 5-(4-nitro-phenyl)-1 p-tolyl-1H-pyrazole | HCID 90032853 | — |
| Product | 3-(4-Fluoro-phenyl)-5-(2-p-tolyl-2H-pyrazol-3-yl)-benzo[c]isoxazole | HCID 73053003 | — |
Reaction Steps
The title compound, light grey solid (50 mg, 38%), MS (ISP) m/z=370.2 [(M+H)+], mp 173° C., was prepared in accordance with the general method of example 1 from 5-(4-nitro-phenyl)-1 p-tolyl-1H-pyrazole (intermediate E) (100 mg, 353 μmol) and commercially available 2-(4-fluoro-phenyl)-acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440962B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-660f030524904b4982d3f5c31ee5cdd3 |
| Source note | uspto-grants-2016_09 |