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4-(Trifluoromethyl)phenylacetonitrile → 5-(2-p-Tolyl-2H-pyrazol-3-yl)-3-(4-trifluoromethyl-phenyl)-benzo[c]isoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Trifluoromethyl)phenylacetonitrile | HCID 75359 | — |
| 反応物 | 5-(4-nitro-phenyl)-1 p-tolyl-1H-pyrazole | HCID 90032853 | — |
| 生成物 | 5-(2-p-Tolyl-2H-pyrazol-3-yl)-3-(4-trifluoromethyl-phenyl)-benzo[c]isoxazole | HCID 73053147 | — |
反応手順
The title compound, yellow solid (41 mg, 27%), MS (ISP) m/z=420.2 [(M+H)+], mp 173° C., was prepared in accordance with the general method of example 1 from 5-(4-nitro-phenyl)-1-p-tolyl-1H-pyrazole (intermediate E) (100 mg, 353 μmol) and commercially available 2-(4-trifluoromethyl-phenyl)-acetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09440962B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-54e9cd09cdeb4649857804175a5b0fa8 |
| 出典メモ | uspto-grants-2016_09 |