4-Chlorobenzyl cyanide → 3-(4-Chloro-phenyl)-5-(2-p-tolyl-2H-pyrazol-3-yl)-benzo[c]isoxazole

Participants

Reaction Steps

The title compound, light green solid (107 mg, 78%), MS (ISP) m/z=386.2 [(M+H)+], mp 204° C., was prepared in accordance with the general method of example 1 from 5-(4-nitro-phenyl)-1-p-tolyl-1H-pyrazole (intermediate E) (100 mg, 353 μmol) and commercially available 2-(4-chloro-phenyl)-acetonitrile.

Provenance & Evidence