HuagongsheHuagongshe Chemistry Print Report · For research reference only
Anthranilamide → HCID 57737846, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Anthranilamide | HCID 6942 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Bromo-1,3-thiazole-4-carboxylic acid | HCID 2763209 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57737846 | HCID 57737846 | 89.9% |
Reaction Steps
2-Bromo-4-thiazolecarboxylic acid (1 g), HATU (2.01 g) and 2-aminobenzamide (0.65 g) are introduced into N,N-dimethylformamide (DMF) (20 ml). The mixture is cooled with an ice bath, and N,N-diisopropylethylamine (0.90 ml) is added. The reaction mixture is stirred at room temperature for 6 days, poured into ice-water and allowed to thaw with stirring, and the precipitated solid is filtered off with suction, washed twice with water, twice with diethyl ether and dried in vacuo. Intermediate III.2 is obtained as a solid (1.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897626B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-77731f6d97124e189f08fdc3451fd289 |
| Source note | uspto-grants-2011_03 |