HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzeneacetonitrile, 4-fluoro- → 5-[2-(2,4-Difluoro-phenyl)-2H-pyrazol-3-yl]-3-(4-fluoro-phenyl)-benzo[c]isoxazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzeneacetonitrile, 4-fluoro- | HCID 68016 | — |
| Edukt | 1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole | HCID 90033224 | — |
| Produkt | 5-[2-(2,4-Difluoro-phenyl)-2H-pyrazol-3-yl]-3-(4-fluoro-phenyl)-benzo[c]isoxazole | HCID 73053295 | — |
Reaktionsschritte
The title compound, light grey solid (22 mg, 17%), MS (ISP) m/z=392.2 [(M+H)+], mp 149° C., was prepared in accordance with the general method of example 1 from 1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate I) (100 mg, 353 μmol) and commercially available 2-(4-fluoro-phenyl)-acetonitrile.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09440962B2 |
| Quelldatensatz | uspto-grants-2016_09 |
| ORD ID | ord-3427a8f1543647a382dd529af7ab6165 |
| Quellennotiz | uspto-grants-2016_09 |