HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Tolylacetonitrile → 5-[2-(2,4-Difluoro-phenyl)-2H-pyrazol-3-yl]-3-p-tolyl-benzo[c]isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Tolylacetonitrile | HCID 76280 | — |
| Reactant | 1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole | HCID 90033224 | — |
| Product | 5-[2-(2,4-Difluoro-phenyl)-2H-pyrazol-3-yl]-3-p-tolyl-benzo[c]isoxazole | HCID 73050955 | — |
Reaction Steps
The title compound, light yellow solid (13 mg, 10%), MS (ISP) m/z=388.2 [(M+H)+], mp 147° C., was prepared in accordance with the general method of example 1 from 1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate I) (100 mg, 353 μmol) and commercially available 2-(p-tolyl)-acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440962B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-3f1c34642f704789aef1248c772f4bca |
| Source note | uspto-grants-2016_09 |