HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)phenylacetonitrile → 5-[2-(2,4-Difluoro-phenyl)-2H-pyrazol-3-yl]-3-(4-trifluoromethyl-phenyl)-benzo[c]isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)phenylacetonitrile | HCID 75359 | — |
| Reactant | 1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole | HCID 90033224 | — |
| Product | 5-[2-(2,4-Difluoro-phenyl)-2H-pyrazol-3-yl]-3-(4-trifluoromethyl-phenyl)-benzo[c]isoxazole | HCID 73050956 | — |
Reaction Steps
The title compound, light yellow solid (18 mg, 12%), MS (ISP) m/z=442.2 [(M+H)+], mp 159° C., was prepared in accordance with the general method of example 1 from 1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate I) (100 mg, 353 μmol) and commercially available 2-(4-trifluoromethyl-phenyl)-acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440962B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-f115a77c93cf4e03a89447568917deaa |
| Source note | uspto-grants-2016_09 |