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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 598478Generated: October 30, 2026

2-Methoxy-5-(trifluoromethyl)aniline → 3-(4-Aminophenoxy)benzoic acid

https://huagongshe.com/reaction/598478

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methoxy-5-(trifluoromethyl)anilineHCID 600637—
ReactantBenzene, 2-isocyanato-1-methoxy-4-(trifluoromethyl)-HCID 11983909—
Reactant3-(4-Aminophenoxy)benzoic acidHCID 23009036—
Product3-(4-Aminophenoxy)benzoic acidHCID 23009036—
ProductHCID 54516399HCID 54516399—

Reaction Steps

Entry 35: 4-(3-Carboxyphenoxy)aniline was synthesized according to Method A11. 5-(Trifluoromethyl)-2-methoxyaniline was converted into 5-(trifluoromethyl)-2-methoxyphenyl isocyanate according to Method B1. 4-(3-Carboxyphenoxy)aniline was reacted with 5-(trifluoromethyl)-2-methoxyphenyl isocyanate according to Method C1f to afford N-(5-(trifluoromethyl)-2-methoxyphenyl)-N-(3-carboxyphenyl) urea, which was coupled with N-(4-fluorophenyl)piperazine according to Method D1c.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07897623B2
Source datasetuspto-grants-2011_03
ORD IDord-e20664e40e0e4b35b70dbead3acc4f53
Source noteuspto-grants-2011_03