4-Chlorobenzyl cyanide → 3-(4-Chloro-phenyl)-5-[2-(2,4-difluoro-phenyl)-2H-pyrazol-3-yl]-benzo[c]isoxazole

Participants

Reaction Steps

The title compound, light green solid (71 mg, 53%), MS (ISP) m/z=408.2 [(M+H)+], mp 155° C., was prepared in accordance with the general method of example 1 from 1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate I) (100 mg, 353 μmol) and commercially available 2-(4-chloro-phenyl)-acetonitrile.

Provenance & Evidence