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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 598482Generated: October 29, 2026

2-Methoxy-5-(trifluoromethyl)aniline → 3-(4-Aminophenoxy)benzoic acid

https://huagongshe.com/reaction/598482

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methoxy-5-(trifluoromethyl)anilineHCID 600637—
ReactantBenzene, 2-isocyanato-1-methoxy-4-(trifluoromethyl)-HCID 11983909—
Reactant3-(4-Aminophenoxy)benzoic acidHCID 23009036—
Product3-(4-Aminophenoxy)benzoic acidHCID 23009036—
ProductN-(5-(trifluoromethyl)-2-methoxyphenyl)-N'-(3-carboxyphenyl)ureaHCID 23614600—

Reaction Steps

Entry 39: 4-(3-Carboxyphenoxy)aniline was synthesized according to Method A11. 5-(Trifluoromethyl)-2-methoxyaniline was converted into 5-(trifluoromethyl)-2-methoxyphenyl isocyanate according to Method B1. 4-(3-Carboxyphenoxy)aniline was reacted with 5-(trifluoromethyl)-2-methoxyphenyl isocyanate according to Method C1f to afford N-(5-(trifluoromethyl)-2-methoxyphenyl)-N′-(3-carboxyphenyl) urea, which was coupled with 4-morpholinoaniline according to Method D1c.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07897623B2
Source datasetuspto-grants-2011_03
ORD IDord-9bdaf058770b4d36b98e055287752197
Source noteuspto-grants-2011_03