HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (7-Chloro-quinazolin-2-yl)-piperidin-3-yl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-BOC-3-Aminopiperidine | HCID 545809 | — |
| Reactant | 2,7-Dichloroquinazoline | HCID 12413929 | — |
| Reactant | (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-yl-amine | HCID 57748894 | — |
| Product | (7-Chloro-quinazolin-2-yl)-piperidin-3-yl-amine | HCID 57748966 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-yl-amine; hydrochloride (example 1, step 1) the title compound was prepared from 2,7-dichloro-quinazoline (Synthesis 1978, 5, 379-82) and 3-Amino-piperidine-1-carboxylic acid tert-butyl ester (commercially available) and subsequent cleavage of the tert-butyl oxy carbonyl protecting group under acidic conditions. (MH+) 263.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897627B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-b52b91ea5590466395e053fadafa4283 |
| Source note | uspto-grants-2011_03 |