Benzeneacetonitrile, 4-fluoro- → HCID 73051107, compound

HRID 59851Notes

Reaction equation

HRID 59851 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[N:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([O-:3])=O.[F:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28]C#N)=[CH:24][CH:23]=1>>[F:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[O:3][N:1]=[C:4]3[CH:9]=[CH:8][C:7]([C:10]4[N:14]([C:15]5[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=5)[N:13]=[CH:12][CH:11]=4)=[CH:6][C:5]=23)=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 68016Benzeneacetonitrile, 4-fluoro-HCID 90030972HCID 90030972, compound2×

Product 1

HCID 73051107HCID 73051107, compound

Procedure

The title compound, light green solid (65 mg, 49%), MS (ISP) m/z=357.1 [(M+H)+], mp 175° C., was prepared in accordance with the general method of example 1 from 2-[5-(4-Nitro-phenyl)-pyrazol-1-yl]-pyridine (intermediate K) (100 mg, 353 μmol) and commercially available 2-(4-fluoro-phenyl)-acetonitrile.

Sources & evidence

ORD record
ord-fb1176580bb44e00a26ac3f0a1c09aab
Source dataset
uspto-grants-2016_09
Patent number
US09440962B2

Reaction notes

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