HCID 57748824, compound → HCID 57748853, compound

HRID 598527Notes

Reaction equation

HRID 598527 reaction equation
CS([C:5]1[S:6][C:7]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:8]=2[N:9]=1)(=O)=O.[NH2:18][C@@H:19]1[CH2:23][CH2:22][N:21]([C:24]([C:26]2[C:31]([O:32][CH3:33])=[CH:30][CH:29]=[CH:28][C:27]=2[O:34][CH3:35])=[O:25])[CH2:20]1>>[CH3:35][O:34][C:27]1[CH:28]=[CH:29][CH:30]=[C:31]([O:32][CH3:33])[C:26]=1[C:24]([N:21]1[CH2:22][CH2:23][C@@H:19]([NH:18][C:5]2[S:6][C:7]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:8]=3[N:9]=2)[CH2:20]1)=[O:25]

Participants

3

Reactant 2

HCID 57748824HCID 57748824, compound2×HCID 577488522-(Methylsulfonyl)-5-(trifluoromethyl)benzothiazole

Product 1

HCID 57748853HCID 57748853, compound

Procedure

In analogy to the procedure described for example 202, step 4, the title compound was prepared from 2-methanesulfonyl-5-trifluoromethyl-benzothiazole and ((R)-3-Amino-pyrrolidin-1-yl)-(2,6-dimethoxy-phenyl)-methanone (Intermediate 5). (M+H+) 452.2.

Sources & evidence

ORD record
ord-d3222b6232834274895d0805d2035dc2
Source dataset
uspto-grants-2011_03
Patent number
US07897627B2

Reaction notes

Loading…