4-Chlorobenzyl cyanide → HCID 73051257, compound

HRID 59854Notes

Reaction equation

HRID 59854 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=O)=[CH:15][CH:14]=2)=[CH:11][CH:10]=[N:9]1.[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29]C#N)=[CH:25][CH:24]=1>>[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[O:21][N:19]=[C:16]3[CH:17]=[CH:18][C:13]([C:12]4[N:8]([C:3]5[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=5[Cl:1])[N:9]=[CH:10][CH:11]=4)=[CH:14][C:15]=23)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 2415824-Chlorobenzyl cyanideHCID 900325511-(2-chloro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole2×

Product 1

HCID 73051257HCID 73051257, compound

Procedure

The title compound, grey solid (110 mg, 81%), MS (ISP) m/z=406.2 [(M+H)+], mp 172° C., was prepared in accordance with the general method of example 1 from 1-(2-chloro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate L) (100 mg, 353 μmol) and commercially available 2-(4-chloro-phenyl)-acetonitrile.

Sources & evidence

ORD record
ord-48af345c93c449fdb5abca945ea21247
Source dataset
uspto-grants-2016_09
Patent number
US09440962B2

Reaction notes

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