4-Bromo-1-benzofuran → (RS)-2-[1-(4-Bromo-benzofuran-2-yl)-methanoyl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 598571Notes

Reaction equation

HRID 598571 reaction equation
[Br:1][C:2]1[C:7]2[CH:8]=[CH:9][O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:11]([O:15][C:16]([N:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH:19]1[C:24](=[O:29])N(OC)C)=[O:17])([CH3:14])([CH3:13])[CH3:12]>>[C:11]([O:15][C:16]([N:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH:19]1[C:24]([C:9]1[O:10][C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([Br:1])[C:7]=2[CH:8]=1)=[O:29])=[O:17])([CH3:14])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 151587214-Bromo-1-benzofuranHCID 21988510tert-Butyl 2-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

Product 1

HCID 66967874(RS)-2-[1-(4-Bromo-benzofuran-2-yl)-methanoyl]-piperidine-1-carboxylic acid tert-butyl ester

Procedure

The title compound (1.45 g) was prepared from 4-bromo-benzofuran (3.65 g, WO0109111) and (RS)-1-(tert-butyloxycarbonyl)-2-(N-methoxy-N-methylcarbamoyl)-piperidine, D1 (5.17 g) according to a procedure similar to that for Description 2.

Sources & evidence

ORD record
ord-12b30139f0a6432795e0e2d15b5c6861
Source dataset
uspto-grants-2011_03
Patent number
US07897618B2

Reaction notes

Loading…