2-Methyl-5-(4-fluorophenyl)thiazole-4-carbonyl chloride → HCID 23146331, compound

HRID 598579Notes

Reaction equation

HRID 598579 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([CH3:13])=[N:10][C:9]=2[C:14](Cl)=[O:15])=[CH:4][CH:3]=1.[O:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[C:18]1[C:26]([CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][NH:29]1)=[O:27]>>[O:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[C:18]1[C:26]([CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][N:29]1[C:14]([C:9]1[N:10]=[C:11]([CH3:13])[S:12][C:8]=1[C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)=[O:15])=[O:27]

Participants

3

Reactant 2

HCID 223241192-Methyl-5-(4-fluorophenyl)thiazole-4-carbonyl chlorideHCID 23146318HCID 23146318, compound

Product 1

HCID 23146331HCID 23146331, compound

Procedure

The title compound was prepared, using the method of Example 1, from 5-(4-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl chloride (0.1 g, 0.39 mmol) and (RS)-1-benzofuran-2-yl-1-piperidin-2-yl-methanone, D9 (0.1 g, 0.43 mmol) as a colourless solid (0.074 g, 43%)

Sources & evidence

ORD record
ord-57c5539d979946198909d3220c0f9b49
Source dataset
uspto-grants-2011_03
Patent number
US07897618B2

Reaction notes

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