5-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid → (RS)-1-[5-(4-Fluoro-phenyl)-2-methyl-thiazol-4-yl]-1-(2-furo [3,2-b]-pyridin-2-ylmethyl-piperidin-1-yl)methanone

HRID 598600Notes

Reaction equation

HRID 598600 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([CH3:13])=[N:10][C:9]=2[C:14]([OH:16])=O)=[CH:4][CH:3]=1.[NH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]1[CH2:23][C:24]1[O:32][C:31]2[C:26](=[N:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:12][C:11]([CH3:13])=[N:10][C:9]=2[C:14]([N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]2[CH2:23][C:24]2[O:32][C:31]3[C:26](=[N:27][CH:28]=[CH:29][CH:30]=3)[CH:25]=2)=[O:16])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 223241255-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acidHCID 23146382HCID 23146382, compound

Product 1

HCID 23146339(RS)-1-[5-(4-Fluoro-phenyl)-2-methyl-thiazol-4-yl]-1-(2-furo [3,2-b]-pyridin-2-ylmethyl-piperidin-1-yl)methanone

Procedure

The title compound was prepared using the method of Example 4, from 5-(4-fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid (120 mg, 0.5 mmol) and (RS)-2-piperidin-2-ylmethyl-furo[3,2-b]pyridine, D47 (108 mg, 0.5 mmol), as a colourless solid (95 mg, 43%).

Sources & evidence

ORD record
ord-ba2fd69b5a354ffb84a5342e272db730
Source dataset
uspto-grants-2011_03
Patent number
US07897618B2

Reaction notes

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